Association of Thyroid Dysfunction with Unexplained Infertility in Women of Karachi Pakistan

Background: Thyroid autoimmunity and thyroid dysfunction is predominant in women of procreative age has been linked with hostile fertility. Objective: To evaluate the association unexplained infertility (UI). Material Methods: A case-control study was performed by department Physiology Basic Medical Sciences Institute collaboration Jinnah Postgraduate Centre, Karachi from May 2018 to June 2019. sample size 88 subjects; Group (44 healthy fertile controls) B UI women) calculated. Study variables included height, weight, body mass index, serum Triiodothyronine (T3), Thyroxine (T4), Thyroid-stimulating Hormone (TSH), Binding Globulin (TBG), Anti-thyroid peroxidase antibody (Anti -TPO). Results: females had high TSH concentration without any disturbance T3 T4 comparison controls, 40% levels higher than 2.5 mIU/L as compared 4% controls. The mean 2.47±1.97mIU/L 1.10±2.14 Both logistic regression models adjusted for index showed that controls were significantly less likely be found (aOR=0.71, 95% CI: 0.52-0.98, p=0.040) TBG (aOR=088, 0.81-0.95, p=0.002) UI. Conclusion: Minimal deviation (increased), raised anti-thyroid antibodies slightly low observed females. Mild variations within normal range may contribute some cases therefore a direct need profile assessment all infertile recommended.